抗原诱导的菌株特异性自身抗独特型抗体调节对右旋糖酐B 512的免疫反应。
Antigen-induced strain-specific autoantiidiotypic antibodies modulate the immune response to dextran B 512.
作者信息
Fernandez C, Möller G
出版信息
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5944-7. doi: 10.1073/pnas.76.11.5944.
Abstract
Sera from CBA and C57BL mice immunized against dextran B 512 eight or more days earlier contain mainly IgG antibodies that specifically suppress the development of plaque-forming cells against dextran in vitro. Suppression was not caused by antibodies against the alpha 1-6 epitope of dextran to any major extent. Sera from CBA mice (IgCH allotype j) suppressed plaque-forming cells from CBA mice, whereas sera from C57BL mice (allotype b) inhibited plaques from C57BL and CBA/Ig-1b mice. Sera from dextran-tolerant mice or from mice that are genetic unresponders to dextran did not suppress plaque-forming cells. Both thymus-independent and thymus-dependent forms of dextran induced the appearance of these autoantiidiotypic antibodies that can distinguish between anti-alpha 1-6 antibodies produced in mouse strains having different IgCH-locus-determined allotypes.
摘要
在八天或更早之前用葡聚糖B 512免疫的CBA和C57BL小鼠的血清，主要含有IgG抗体，这些抗体在体外能特异性抑制针对葡聚糖的噬斑形成细胞的发育。抑制作用在很大程度上并非由针对葡聚糖α1-6表位的抗体引起。CBA小鼠（IgCH同种异型j）的血清抑制CBA小鼠的噬斑形成细胞，而C57BL小鼠（同种异型b）的血清则抑制C57BL和CBA/Ig-1b小鼠的噬斑。来自葡聚糖耐受小鼠或对葡聚糖无遗传反应的小鼠的血清不抑制噬斑形成细胞。胸腺非依赖性和胸腺依赖性形式的葡聚糖均诱导这些自身抗独特型抗体的出现，这些抗体能够区分在具有不同IgCH基因座决定的同种异型的小鼠品系中产生的抗α1-6抗体。
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本文引用的文献
1
Plaque formation in agar by single antibody-producing cells.单个产生抗体的细胞在琼脂中形成菌斑。
Science. 1963 Apr 26;140(3565):405.
2
Towards a network theory of the immune system.迈向免疫系统的网络理论。
Ann Immunol (Paris). 1974 Jan;125C(1-2):373-89.
3
Regulation of immune response by autogenous antibody against receptor.自身抗受体抗体对免疫反应的调节
Proc Natl Acad Sci U S A. 1974 Dec;71(12):5083-7. doi: 10.1073/pnas.71.12.5083.
4
Detection of anti-idiotype reactive cells in the response to phosphorylcholine.在对磷酸胆碱的反应中抗独特型反应性细胞的检测。
Eur J Immunol. 1976 Feb;6(2):114-6. doi: 10.1002/eji.1830060208.
5
Immunological tolerance to the thymus-independent antigen dextran can be abrogated by thymus-dependent dextran conjugates: evidence against clonal deletion as the mechanism of tolerance induction.对胸腺非依赖性抗原葡聚糖的免疫耐受性可被胸腺依赖性葡聚糖缀合物消除：反对克隆清除作为耐受性诱导机制的证据。
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Irreversible immunological tolerance to thymus-independent antigens is restricted to the clone of B cells having both Ig and PBA receptors for the tolerogen.对胸腺非依赖性抗原的不可逆免疫耐受限于对该耐受原同时具有免疫球蛋白（Ig）和多聚体鞭毛抗原（PBA）受体的B细胞克隆。
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