晚期糖基化终产物诱导视网膜穆勒细胞表达血管内皮生长因子。
Advanced glycation end products induce expression of vascular endothelial growth factor by retinal Muller cells.
作者信息
Hirata C, Nakano K, Nakamura N, Kitagawa Y, Shigeta H, Hasegawa G, Ogata M, Ikeda T, Sawa H, Nakamura K, Ienaga K, Obayashi H, Kondo M
机构信息
First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kamikyo-ku, Japan.
出版信息
Biochem Biophys Res Commun. 1997 Jul 30;236(3):712-5. doi: 10.1006/bbrc.1997.7036.
Recent studies have suggested that advanced glycation end products (AGEs) are involved in the development of diabetic complications. To assess the pathogenic role of AGEs and vascular endothelial growth factor (VEGF) in the development of retinal neovascularization in diabetic retinopathy, we investigated the effect of AGEs on induction of VEGF by retinal Muller cells and measured AGE and VEGF concentrations in the vitreous of patients with proliferative diabetic retinopathy (PDR) and nondiabetic patients. The expression of VEGF mRNA and the production of VEGF protein by cultured Muller cells were enhanced by the presence of AGEs. The vitreous concentrations of AGEs and VEGF were both elevated in patients with PDR compared with patients without diabetes (P < 0.01). There was a moderate positive correlation between the levels of crossline and VEGF (r=0.698, P < 0.01). Elevation of AGEs in the vitreous may promote intraocular neovascularization in diabetic retinopathy through production of VEGF from Muller cells.
最近的研究表明，晚期糖基化终末产物（AGEs）参与糖尿病并发症的发生发展。为了评估AGEs和血管内皮生长因子（VEGF）在糖尿病视网膜病变视网膜新生血管形成中的致病作用，我们研究了AGEs对视网膜Muller细胞诱导VEGF的影响，并测量了增殖性糖尿病视网膜病变（PDR）患者和非糖尿病患者玻璃体中AGEs和VEGF的浓度。AGEs的存在增强了培养的Muller细胞中VEGF mRNA的表达和VEGF蛋白的产生。与非糖尿病患者相比，PDR患者玻璃体中AGEs和VEGF的浓度均升高（P < 0.01）。交联水平与VEGF水平之间存在中度正相关（r = 0.698，P < 0.01）。玻璃体中AGEs的升高可能通过Muller细胞产生VEGF促进糖尿病视网膜病变中的眼内新生血管形成。
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