Alvarez-Granda L, Cabero-Perez M J, Bustamante-Ruiz A, Gonzalez-Lamuño D, Delgado-Rodriguez M, García-Fuentes M
Department of Paediatrics, University Hospital of Valdecilia, Santander, Spain.
Thorax. 1997 Jul;52(7):659-61. doi: 10.1136/thx.52.7.659.
A study was undertaken to clarify whether the PI SZ phenotype of the protease inhibitor system predisposes to chronic obstructive pulmonary disease (COPD).
The prevalence of PI Z and PI SZ deficient phenotypes was investigated in a population of 702 patients with COPD followed up at the Chest Unit of a tertiary hospital and in 15400 newborn infants from the same geographical area. Individuals with deficiency were detected by screening of dried blood spots on filter paper using a comparative electro-immunodiffusion technique for alpha 1-antitrypsin and transferrin. The serum phenotype was confirmed by means of isoelectrofocusing on polyacrylamide gel.
Of the 702 blood samples from patients with COPD, six PI Z subjects (0.85%) and one PI SZ (0.14%) were detected. Of the 15400 samples from neonates, the number of PI Z subjects was eight (0.052%) and that of PI SZ was 24 (0.156%). The difference between the two groups was significant for PI Z but not for PI SZ.
The data do not indicate an increased risk for development of COPD associated with the PI SZ phenotype but confirm the predisposition of PI Z individuals for the development of COPD.
开展了一项研究以明确蛋白酶抑制剂系统的PI SZ表型是否易患慢性阻塞性肺疾病（COPD）。
在一家三级医院胸科随访的702例COPD患者群体以及来自同一地理区域的15400例新生儿中，调查PI Z和PI SZ缺陷表型的患病率。通过使用针对α1 -抗胰蛋白酶和转铁蛋白的比较电免疫扩散技术筛选滤纸上的干血斑来检测缺陷个体。血清表型通过在聚丙烯酰胺凝胶上进行等电聚焦来确认。
在702例COPD患者的血样中，检测到6例PI Z个体（0.85%）和1例PI SZ个体（0.14%）。在15400例新生儿样本中，PI Z个体有8例（0.052%），PI SZ个体有24例（0.156%）。两组之间PI Z的差异有统计学意义，而PI SZ无统计学意义。
数据未表明PI SZ表型与COPD发生风险增加相关，但证实了PI Z个体易患COPD。
