Terada T, Ohta T, Kitamura Y, Ashida K, Matsunaga Y, Kato M
Second Department of Pathology, Tottori University Faculty of Medicine, Yonago, Japan.
Virchows Arch. 1997 Jul;431(1):31-6. doi: 10.1007/s004280050066.
The endocrine cells in intraductal papillary-mucinous neoplasms (IPN) of the pancreas have rarely been investigated. In the normal pancreatic ducts of normal pancreases (n = 5) there were a few endocrine cells: argyrophil in 5 (100%), chromogranin A in (100%), pancreatic polypeptide (PP) in 3 (60%), and insulin in 7 (20%). These endocrine cells were scattered, and located in the basal portions of pancreatic ducts. In IPN of the pancreas (n = 9), there were many endocrine cells: argyrophil in 7 (78%), argentaffin in 8 (89%), chromogranin A in 8 (89%), PP in 7 (78%), serotonin in 7 (78%), insulin in 4 (44%), and gastrin in 5 (56%). In invasive ductal adenocarcinoma of the pancreas (n = 6), many endocrine cells were also detected: argyrophil cells in (67%), chromogranin A in 3 (50%), insulin in 3 (50%), glucagon in 4 (67%), and somatostatin in 3 (50%). In positive cases, endocrine cells were situated under or among the neoplastic cells and the proportion of endocrine cells in IPN was less than 5% of the total neoplastic cell population. These data show that normal pancreatic ducts contain endocrine cells and that IPN frequently contain argyrophil, argentaffin, chromogranin A, and hormone-containing endocrine cells. These data also suggest that endocrine differentiation occurs during neoplastic transformation and progression of IPN of the pancreas.
胰腺导管内乳头状黏液性肿瘤（IPN）中的内分泌细胞很少被研究。在正常胰腺（n = 5）的正常胰管中，有少量内分泌细胞：嗜银细胞5个（100%），嗜铬粒蛋白A阳性（100%），胰多肽（PP）3个（60%），胰岛素7个（20%）。这些内分泌细胞散在分布，位于胰管的基底部分。在胰腺IPN（n = 9）中，有许多内分泌细胞：嗜银细胞7个（78%），亲银细胞8个（89%），嗜铬粒蛋白A阳性8个（89%），PP 7个（78%），血清素7个（78%），胰岛素4个（44%），胃泌素5个（56%）。在胰腺浸润性导管腺癌（n = 6）中，也检测到许多内分泌细胞：嗜银细胞（67%），嗜铬粒蛋白A阳性3个（50%），胰岛素3个（50%），胰高血糖素4个（67%），生长抑素3个（50%）。在阳性病例中，内分泌细胞位于肿瘤细胞之下或之中，IPN中内分泌细胞的比例不到肿瘤细胞总数的5%。这些数据表明正常胰管含有内分泌细胞，IPN经常含有嗜银、亲银、嗜铬粒蛋白A和含激素的内分泌细胞。这些数据还提示在胰腺IPN的肿瘤转化和进展过程中发生了内分泌分化。
