Julien C, Bertolino S, Medeiros I A, Barrès C, Sassard J
Département de Physiologie et Pharmacologie Clinique, CNRS ESA 5014, Faculté de Pharmacie, Lyon, France.
Clin Exp Hypertens. 1997 Jul-Aug;19(5-6):699-711. doi: 10.3109/10641969709083180.
In genetically hypertensive rats of Lyon strain (LH), both development and maintenance of hypertension are extremely sensitive to the chronic blockade of the renin-angiotensin system. However, LH rats exhibit a low renin secretory profile as indicated by (1) low basal plasma renin concentration; (2) blunted renin responses to reductions of renal perfusion pressure and beta-adrenoceptor stimulation both in vitro (isolated perfused kidney) and in vivo (conscious rat). None of the latter abnormalities are corrected by chronic sodium deprivation or when hypertension is prevented by hydralazine or perindopril treatment. Future studies will therefore have to elucidate the 'renin paradox' in LH rats.
在里昂品系（LH）的遗传性高血压大鼠中，高血压的发生和维持对肾素 - 血管紧张素系统的慢性阻断极为敏感。然而，LH大鼠表现出低肾素分泌特征，表现为：（1）基础血浆肾素浓度低；（2）无论是在体外（离体灌注肾脏）还是在体内（清醒大鼠），肾素对肾灌注压降低和β - 肾上腺素能受体刺激的反应均减弱。慢性钠缺乏、或用肼屈嗪或培哚普利治疗预防高血压时，后述异常均未得到纠正。因此，未来的研究将必须阐明LH大鼠中的“肾素悖论”。
