Scott D W, Schultz R D
J Am Vet Med Assoc. 1977 Oct 15;171(8):721-7.
Epidermolysis bullosa simplex was diagnosed in 4 Collie dogs. Three of the dogs were less than 6 months old when lesions were first noticed. Lesions were characterized by alopecia, erythema, edema, erythematous plaques, erosions, ulcers, crusts, atrophy, pigmentary changes, and (rarely) blisters affecting the skin over bony prominences and joints of the limbs, face, lips, and ears. Minimal to moderate pruritus or pain was manifested by chewing and licking at the affected areas of the limbs and by pawing and rubbing at the face and ears. Lesions could be induced by frictional trauma in areas of normal skin. Diagnosis was confirmed by histologic examination of affected tissues and induced lesions. Therapy with large oral doses of prednisolone and avoidance of trauma were palliative.
4只柯利犬被诊断为单纯性大疱性表皮松解症。其中3只犬在首次发现病变时年龄小于6个月。病变的特征为脱发、红斑、水肿、红斑性斑块、糜烂、溃疡、结痂、萎缩、色素沉着变化，以及（罕见）水疱，累及四肢、面部、嘴唇和耳朵的骨隆突和关节处的皮肤。通过舔舐和啃咬四肢的患病部位，以及用爪子抓挠和摩擦面部和耳朵，表现出轻度至中度瘙痒或疼痛。正常皮肤区域的摩擦创伤可诱发病变。通过对受影响组织和诱发病变的组织学检查确诊。大剂量口服泼尼松龙治疗并避免创伤具有缓解作用。
