Sundman K, Arneborn P, Blad L, Sjöberg L, Vikerfors T
Department of Infectious Diseases, Orebro Medical Center Hospital, Sweden.
Eur J Clin Microbiol Infect Dis. 1997 Jun;16(6):455-8. doi: 10.1007/BF02471910.
The efficacy and safety of two different regimens for parenteral treatment of presumed severe febrile urinary tract infection were compared in a randomized study. One hundred fifty-eight patients were treated with either cefotaxime 2 g i.v. twice daily for at least two days followed by norfloxacin 400 mg twice daily orally or one bolus dose of gentamicin 3 mg/kg i.v. and norfloxacin from the start. Three patients randomized to cefotaxime died. Of the 101 patients with verified urinary tract infection, clinical response to assigned therapy was seen in 79% and 74%, respectively. There was no difference in fever duration between the two regimens. The results indicate that one bolus dose of gentamicin with early oral therapy is a safe and effective alternative to common parenteral regimens for empirical treatment of febrile urinary tract infection.
在一项随机研究中，比较了两种不同方案用于胃肠外治疗疑似严重发热性尿路感染的疗效和安全性。158例患者接受以下两种治疗之一：每日两次静脉注射头孢噻肟2g，至少持续两天，随后每日两次口服诺氟沙星400mg；或者从一开始就静脉注射一次大剂量庆大霉素3mg/kg并口服诺氟沙星。随机分配接受头孢噻肟治疗的3例患者死亡。在101例确诊为尿路感染的患者中，分别有79%和74%的患者对指定治疗有临床反应。两种治疗方案的发热持续时间没有差异。结果表明，对于发热性尿路感染的经验性治疗，一次大剂量庆大霉素联合早期口服治疗是常规胃肠外治疗方案的一种安全有效的替代方案。
