静脉注射氯丙嗪与肌肉注射舒马曲坦治疗急性偏头痛的比较。
Intravenous chlorpromazine versus intramuscular sumatriptan for acute migraine.
作者信息
Kelly A M, Ardagh M, Curry C, D'Antonio J, Zebic S
机构信息
Emergency Department, Western Hospital, Melbourne, Australia.
出版信息
J Accid Emerg Med. 1997 Jul;14(4):209-11. doi: 10.1136/emj.14.4.209.
Abstract
OBJECTIVE
To establish whether there is any difference in the efficacy of a chlorpromazine regimen and a sumatriptan regimen for the management of the pain of acute severe migraine.
SETTING
Two urban teaching hospital emergency departments.
METHODS
Prospective, randomised, unblinded, crossover trial. All patients received intravenous metoclopramide 10 mg and 1000 ml of normal saline over 1 h; 20 were then randomised to receive intramuscular sumatriptan 6 mg and 23 to receive intravenous chlorpromazine, 12.5 mg increments to a maximum of 37.5 mg. Response to treatment was measured using visual analogue pain scales.
RESULTS
No difference in efficacy between the sumatriptan regimen and the chlorpromazine regimen was found. Adverse effects were mild and equally distributed between the groups.
CONCLUSIONS
The chlorpromazine and sumatriptan regimens studied are both very effective for the relief of the headache of severe migraine.
摘要
目的
确定氯丙嗪方案和舒马曲坦方案在治疗急性重度偏头痛疼痛方面的疗效是否存在差异。
设置
两家城市教学医院急诊科。
方法
前瞻性、随机、非盲、交叉试验。所有患者在1小时内静脉输注10毫克甲氧氯普胺和1000毫升生理盐水；然后将20例患者随机分组接受6毫克舒马曲坦肌肉注射，23例接受静脉注射氯丙嗪，每次增量12.5毫克，最大剂量为37.5毫克。使用视觉模拟疼痛量表测量治疗反应。
结果
未发现舒马曲坦方案和氯丙嗪方案在疗效上存在差异。不良反应轻微，且在两组中分布均匀。
结论
所研究的氯丙嗪和舒马曲坦方案在缓解重度偏头痛头痛方面均非常有效。
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1
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Acad Emerg Med. 1995 Jul;2(7):597-602. doi: 10.1111/j.1553-2712.1995.tb03596.x.
2
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Ann Neurol. 1993 Jan;33(1):48-56. doi: 10.1002/ana.410330109.
3
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Ann Emerg Med. 1995 Apr;25(4):464-9. doi: 10.1016/s0196-0644(95)70259-8.
4
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J Neurol Neurosurg Psychiatry. 1980 Apr;43(4):369-71. doi: 10.1136/jnnp.43.4.369.
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6
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