甲氧氯普胺治疗偏头痛发作的双盲研究。
A double blind study of metoclopramide in the treatment of migraine attacks.
作者信息
Tfelt-Hansen P, Olesen J, Aebelholt-Krabbe A, Melgaard B, Veilis B
出版信息
J Neurol Neurosurg Psychiatry. 1980 Apr;43(4):369-71. doi: 10.1136/jnnp.43.4.369.
Abstract
One hundred and fifty patients with migraine attacks attending the Copenhagen acute migraine clinic were treated either with metoclopramide 10 mg i.m. metoclopramide 20 mg as suppository or placebo in a double blind trial. All patients simultaneously or 30 minutes later received paracetamol 1 g and diazepam 5 mg orally. The nausea was relieved in 71% of the patients by placebo and bed rest, but metoclopramide was significantly (p = 0.04) more effective and relieved nausea in 86% of the patients. Metoclopramide did not by itself reduce the pain, but enhanced the effect of the analgesic or sedative medication. This effect, however, just failed to be statistically significant (p = 0.06).
摘要
在哥本哈根急性偏头痛诊所就诊的150名偏头痛发作患者，在一项双盲试验中，分别接受10毫克甲氧氯普胺肌肉注射、20毫克甲氧氯普胺栓剂或安慰剂治疗。所有患者在同时或30分钟后口服1克对乙酰氨基酚和5毫克地西泮。安慰剂和卧床休息使71%的患者恶心症状得到缓解，但甲氧氯普胺的效果显著更好（p = 0.04），使86%的患者恶心症状得到缓解。甲氧氯普胺本身并不能减轻疼痛，但增强了镇痛或镇静药物的效果。然而，这种效果在统计学上刚刚未达到显著水平（p = 0.06）。
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