Tracqui A, Kintz P, Cirimele V, Berthault F, Mangin P, Ludes B
Institut de Médecine Légale, Strasbourg, France.
J Anal Toxicol. 1997 Jul-Aug;21(4):314-8. doi: 10.1093/jat/21.4.314.
A fatality that was due to massive ingestion of the thioxanthene neuroleptic (Z)-cis-clopenthixol (zuclopenthixol, Z-CPT) is described. The total toxicological screening and the quantitation of both the ingested drugs and its inactive isomer (E)-trans-clopenthixol (E-CPT, produced by in vivo isomerization) in postmortem fluids and viscerae were produced by high-performance liquid chromatography (HPLC)-diode array detection. Drug confirmation was carried out by HPLC-mass spectrometry with an ionspray interface. Although death occurred 40 h after the drug intake, postmortem blood concentrations were 391 and 275 mg/mL for Z-CPT and E-CPT, respectively (50 to 100 times the usual therapeutic values). The cause of death was suicide, and the manner was acute neuroleptic overdosage.
本文描述了一例因大量摄入噻吨类抗精神病药（Z）-顺式氯哌噻吨（珠氯噻醇，Z-CPT）导致的死亡病例。采用高效液相色谱（HPLC）-二极管阵列检测法对死后体液和脏器中摄入的药物及其无活性异构体（E）-反式氯哌噻吨（E-CPT，由体内异构化产生）进行了全面的毒理学筛查和定量分析。通过带有离子喷雾接口的HPLC-质谱联用仪进行药物确证。尽管服药后40小时死亡，但死后血液中Z-CPT和E-CPT的浓度分别为391和275mg/mL（是通常治疗值的50至100倍）。死因是自杀，死亡方式为急性抗精神病药过量。
