斑贴试验在特应性皮炎中的价值。

Value of patch testing in atopic dermatitis.

作者信息

el Samahy M H, el-Kerdani T

机构信息

Department of Dermatology, Ain Shams University, Egypt.

出版信息

Am J Contact Dermat. 1997 Sep;8(3):154-7.

PMID:9249284

Abstract

BACKGROUND

Because patients with atopic dermatitis are less prone to type IV allergies, there has been controversy regarding the role of patch testing in these patients.

OBJECTIVE

The present study was conducted to evaluate the role of patch testing in atopic individuals.

METHODS

One-hundred patients with hand eczema were patch tested using the standard patch test battery (HERMAL, Kurt Herrmann, Reinbek, West Germany) and the Finn chamber units. The total immunoglobulin class E (IgE) level was determined and correlated to the results of patch testing.

RESULTS

Eighty-seven patients had positive patch test reactions. Among the 87 patients, 39 (44.8%) had atopic dermatitis. The most common allergens yielding positive results were nickel sulfate, 2.5%, (58.6%); potassium dichromate, 0.25% (56.3%); carba mix, 3%, (44.82%); formaldehyde, 1% in H2O, (40.22%); neomycin sulfate, 20%, (33.3%); and balsam of Peru 25%, (17.24%) respectively. Patients with atopic dermatitis were more frequently sensitive to neomycin sulfate than nonatopics.

CONCLUSION

Patients with atopic dermatitis should be patch tested when indicated because they also develop contact allergic sensitization to a significant degree. Our observations indicate that patch testing with standard allergens often adds valuable information about contact sensitivity in these patients.

摘要

背景

由于特应性皮炎患者对IV型过敏的易感性较低，因此关于斑贴试验在这些患者中的作用一直存在争议。

目的

本研究旨在评估斑贴试验在特应性个体中的作用。

方法

使用标准斑贴试验试剂盒（HERMAL，Kurt Herrmann，德国莱茵贝克）和芬兰小室对100例手部湿疹患者进行斑贴试验。测定总免疫球蛋白E（IgE）水平，并将其与斑贴试验结果相关联。

结果

87例患者斑贴试验反应呈阳性。在这87例患者中，39例（44.8%）患有特应性皮炎。产生阳性结果的最常见变应原分别为2.5%硫酸镍（58.6%）；0.25%重铬酸钾（56.3%）；3%卡巴混合物（44.82%）；1%甲醛水溶液（40.22%）；20%硫酸新霉素（33.3%）；25%秘鲁香脂（17.24%）。特应性皮炎患者对硫酸新霉素的敏感性高于非特应性患者。