Kanerva L, Estlander T
Section of Dermatology, Finnish Institute of Occupational Health, Helsinki, Finland.
Am J Contact Dermat. 1997 Sep;8(3):167-9.
Cow dander is the most common cause of occupational contact urticaria in Finland. Occasionally cow dander also causes allergic contact dermatitis, which can be revealed by patch testing with cow dander.
A patient with a combined type I and type IV allergy to cow dander is the subject of this report.
She had intense pruritus, whealing, and severe dermatitis, but no respiratory symptoms. Skin tests and radioallergosorbent test indicated that she had both type I and type IV allergy to cow dander.
Increasing numbers of cases with both type I and type IV allergy are reported, but the mechanism is not clear. In our clinic, we classify immediate reactions as contact urticaria if the clinical picture involves whealing, and as protein contact dermatitis if dermatitis dominates the clinical picture. If delayed allergic patch test results are obtained, we consider it allergic contact dermatitis.
在芬兰，牛毛屑是职业性接触性荨麻疹最常见的病因。偶尔，牛毛屑也会引起过敏性接触性皮炎，通过用牛毛屑进行斑贴试验可揭示这一情况。
本报告的对象是一名对牛毛屑具有I型和IV型过敏合并症的患者。
她有强烈的瘙痒、风团及严重的皮炎，但无呼吸道症状。皮肤试验和放射性变应原吸附试验表明她对牛毛屑同时存在I型和IV型过敏。
报告显示同时存在I型和IV型过敏的病例数量不断增加，但其机制尚不清楚。在我们诊所，如果临床表现涉及风团，我们将即刻反应归类为接触性荨麻疹；如果皮炎在临床表现中占主导，则归类为蛋白质接触性皮炎。如果获得延迟性变应性斑贴试验结果，我们将其视为过敏性接触性皮炎。
