壳聚糖N-硫酸盐。一种水溶性聚电解质。

Chitosan N-sulfate. A water-soluble polyelectrolyte.

作者信息

Holme K R, Perlin A S

机构信息

Department of Chemistry, McGill University, Montreal, Quebec, Canada.

出版信息

Carbohydr Res. 1997 Jul 11;302(1-2):7-12. doi: 10.1016/s0008-6215(97)00117-1.

DOI:10.1016/s0008-6215(97)00117-1

PMID:9249948

Abstract

Chitosans having degrees of acetylation (da) of 0.04, 0.10, and 0.22, respectively, were N-sulfated under a variety of reaction conditions. The derivatives obtained ranged in degree of sulfation (ds) from 0.4 to 0.86 (+/-0.05). All were soluble in water, and the rheological properties of their solutions varied markedly with da and ds values. Both ionic strength and pH had an effect on their solubility properties, and also on interactions that they exhibited with O-(carboxymethyl)cellulose, xanthan gum, and heparin. Being compatible with other polyelectrolytes such as these, the chitosan derivatives may be useful in some aqueous formulations.

摘要

脱乙酰度（da）分别为0.04、0.10和0.22的壳聚糖在各种反应条件下进行N-硫酸化。得到的衍生物的硫酸化度（ds）在0.4至0.86（±0.05）范围内。所有衍生物均溶于水，其溶液的流变性质随脱乙酰度和硫酸化度值的变化而显著不同。离子强度和pH值对它们的溶解性能有影响，对它们与O-（羧甲基）纤维素、黄原胶和肝素的相互作用也有影响。由于与这些聚电解质相容，壳聚糖衍生物在一些水性制剂中可能有用。