Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao, 266071, China.
Key Lab of Biomedical Materials of Natural Macromolecules, Ministry of Education, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, 100029, Beijing, China.
Drug Deliv Transl Res. 2021 Aug;11(4):1340-1351. doi: 10.1007/s13346-021-00913-w. Epub 2021 Jan 26.
Infectious diseases, such as the coronavirus disease-19, SARS virus, Ebola virus, and AIDS, threaten the health of human beings globally. New viruses, drug-resistant bacteria, and fungi continue to challenge the human efficacious drug bank. Researchers have developed a variety of new antiviral and antibacterial drugs in response to the infectious disease crisis. Meanwhile, the development of functional materials has also improved therapeutic outcomes. As a natural material, chitosan possesses good biocompatibility, bioactivity, and biosafety. It has been proven that the cooperation between chitosan and traditional medicine greatly improves the ability of anti-infection. This review summarized the application and design considerations of chitosan-composed systems for the treatment of infectious diseases, looking forward to providing the idea of infectious disease therapy.
传染病,如新型冠状病毒肺炎、严重急性呼吸综合征病毒、埃博拉病毒和艾滋病,威胁着全球人类的健康。新的病毒、耐药细菌和真菌不断挑战着人类有效的药物库。研究人员针对传染病危机开发了多种新型抗病毒和抗菌药物。同时,功能材料的发展也改善了治疗效果。壳聚糖作为一种天然材料,具有良好的生物相容性、生物活性和生物安全性。已经证明,壳聚糖与传统医学的结合大大提高了抗感染的能力。本综述总结了壳聚糖组成体系在治疗传染病中的应用和设计考虑,以期为传染病治疗提供思路。