来自柱状田头菇的具有自由基清除活性的新型吲哚衍生物。

New indole derivatives with free radical scavenging activity from Agrocybe cylindracea.

作者信息

Kim W G, Lee I K, Kim J P, Ryoo I J, Koshino H, Yoo I D

机构信息

Korea Research Institute of Bioscience and Biotechnology, KIST, Yusong, Taejon, Korea.

出版信息

J Nat Prod. 1997 Jul;60(7):721-3. doi: 10.1021/np970150w.

DOI:10.1021/np970150w

PMID:9249978

Abstract

Two new indole derivatives were isolated as free radical scavengers from the MeOH extract of Agrocybe cylindracea. The structures of these compounds were determined to be 6-hydroxy-1H-indole-3-carboxaldehyde (1) and 6-hydroxy-1H-indole-3-acetamide (2) on the basis of spectroscopic studies. Compounds 1 and 2 inhibited lipid peroxidation in rat liver microsomes, with IC50 values of 4.1 and 3.9 micrograms/mL, respectively.

摘要

从柱状田头菇的甲醇提取物中分离出两种新的吲哚衍生物作为自由基清除剂。基于光谱研究，确定这些化合物的结构分别为6-羟基-1H-吲哚-3-甲醛（1）和6-羟基-1H-吲哚-3-乙酰胺（2）。化合物1和2抑制大鼠肝微粒体中的脂质过氧化，IC50值分别为4.1和3.9微克/毫升。