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Cytosolic receptor for aryl hydrocarbon hydroxylase induction by polycyclic aromatic compounds. Evidence for structural and regulatory variants among established cell cultured lines.

作者信息

Guenthner T M, Nebert D W

出版信息

J Biol Chem. 1977 Dec 25;252(24):8981-9.

PMID:925034
Abstract
摘要

相似文献

1
Cytosolic receptor for aryl hydrocarbon hydroxylase induction by polycyclic aromatic compounds. Evidence for structural and regulatory variants among established cell cultured lines.多环芳烃化合物诱导芳烃羟化酶的胞质受体。已建立的细胞培养系中结构和调节变体的证据。
J Biol Chem. 1977 Dec 25;252(24):8981-9.
2
Tissue distribution of the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat.大鼠体内2,3,7,8-四氯二苯并对二噁英受体的组织分布
Cancer Res. 1979 Aug;39(8):3172-6.
3
Ah receptor mediating induction of aryl hydrocarbon hydroxylase: detection in human lung by binding of 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin.芳烃受体介导芳烃羟化酶的诱导：通过2,3,7,8-[³H]四氯二苯并对二恶英结合在人肺中检测。
Cancer Res. 1986 Jul;46(7):3739-43.
4
Comparison of aryl hydrocarbon hydroxylase and acetanilide 4-hydroxylase induction by polycyclic aromatic compounds in human and mouse cell lines.多环芳烃化合物对人和小鼠细胞系中芳烃羟化酶及乙酰苯胺4-羟化酶诱导作用的比较
Biochem Pharmacol. 1985 Aug 1;34(15):2721-31. doi: 10.1016/0006-2952(85)90573-8.
5
Ah receptor in mice genetically "nonresponsive" for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells.对细胞色素P4501A1诱导具有基因“无反应性”的小鼠中的芳烃受体：胞质芳烃受体、向核结合状态的转变以及胚胎组织和细胞中卤代和非卤代芳烃对芳烃羟化酶的诱导。
Mol Pharmacol. 1991 Nov;40(5):818-26.
6
Effects of substituents on the cytosolic receptor-binding avidities and aryl hydrocarbon hydroxylase induction potencies of 7-substituted 2,3-dichlorodibenzo-p-dioxins. A quantitative structure-activity relationship analysis.取代基对7-取代的2,3-二氯二苯并对二噁英的胞质受体结合亲和力和芳烃羟化酶诱导能力的影响。定量构效关系分析。
Mol Pharmacol. 1985 Jun;27(6):656-61.
7
Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.肝脏胞液对2,3,7,8-四氯二苯并对二噁英的立体特异性、高亲和力结合。结合物质是芳烃羟化酶诱导受体的证据。
J Biol Chem. 1976 Aug 25;251(16):4936-46.
8
Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz(a)anthracene in the human A431 squamous cell carcinoma line.2,3,7,8-四氯二苯并对二恶英和苯并(a)蒽对人A431鳞状细胞癌系中芳烃受体的表征及芳烃羟化酶的诱导作用
Cancer Res. 1988 May 1;48(9):2388-95.
9
Polychlorinated dibenzofurans (PCDFs): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity.多氯代二苯并呋喃（PCDFs）：结构对其与2,3,7,8-四氯二苯并对二噁英胞质受体蛋白结合、芳烃羟化酶诱导及毒性的影响
Toxicology. 1984 Aug;32(2):131-44. doi: 10.1016/0300-483x(84)90132-x.
10
Competitive interaction for the Ah receptor by polycyclic aromatic hydrocarbons which do not induce aryl hydrocarbon hydroxylase in C3H/10T1/2 mouse embryo fibroblasts.多环芳烃对Ah受体的竞争性相互作用，这些多环芳烃在C3H/10T1/2小鼠胚胎成纤维细胞中不诱导芳烃羟化酶。
Prog Clin Biol Res. 1983;135:373-7.

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Aryl hydrocarbon receptor as a drug target in advanced prostate cancer therapy - obstacles and perspectives.芳烃受体作为晚期前列腺癌治疗中的药物靶点——障碍与前景
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Role of Hepatic Aryl Hydrocarbon Receptor in Non-Alcoholic Fatty Liver Disease.
肝脏芳烃受体在非酒精性脂肪性肝病中的作用
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Nuclear receptors: a bridge linking the gut microbiome and the host.核受体：连接肠道微生物组和宿主的桥梁。
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Differential Contribution of the Aryl-Hydrocarbon Receptor and Toll-Like Receptor Pathways to IL-8 Expression in Normal and Cystic Fibrosis Airway Epithelial Cells Exposed to .芳烃受体和Toll样受体途径对暴露于……的正常和囊性纤维化气道上皮细胞中白细胞介素-8表达的不同贡献
Front Cell Dev Biol. 2016 Dec 22;4:148. doi: 10.3389/fcell.2016.00148. eCollection 2016.
6
Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs.芳烃受体途径的复杂性；通过多种蛋白质伴侣和DNA基序进行信号传导。
Toxicol Res (Camb). 2015 Sep 1;4(5):1143-1158. doi: 10.1039/c4tx00236a. Epub 2015 Mar 17.
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The evolving role of drug metabolism in drug discovery and development.药物代谢在药物发现与开发中不断演变的作用。
Pharm Res. 2007 May;24(5):842-58. doi: 10.1007/s11095-006-9217-9. Epub 2007 Mar 1.
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Investigation of the causes of the decrease in enzyme induction after prolonged administration of a hormone: reception of cortisol in rat liver cells.长期给予激素后酶诱导作用降低的原因研究：大鼠肝细胞中皮质醇的摄取
Neurosci Behav Physiol. 1982 Sep-Oct;12(5):380-5. doi: 10.1007/BF01189299.
9
The 4S binding protein acts as a trans-regulator of the polycyclic hydrocarbon-inducible cytochrome P450.4S结合蛋白作为多环芳烃诱导型细胞色素P450的反式调节因子。
Cancer Metastasis Rev. 1988 Apr;7(1):51-65. doi: 10.1007/BF00048278.
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The aryl hydrocarbon hydroxylase (Ah) locus and a novel restriction-fragment length polymorphism (RFLP) are located on mouse chromosome 12.芳基烃羟化酶（Ah）基因座和一种新的限制性片段长度多态性（RFLP）位于小鼠第12号染色体上。
Biochem Genet. 1987 Jun;25(5-6):401-13. doi: 10.1007/BF00554549.