Chitnavis J, Sinsheimer J S, Clipsham K, Loughlin J, Sykes B, Burge P D, Carr A J
Nuffield Orthopaedic Centre, Headington, Oxford, England.
J Bone Joint Surg Br. 1997 Jul;79(4):660-4. doi: 10.1302/0301-620x.79b4.7437.
From a prospective, cross-sectional survey of 402 patients who had a total hip (THR) or a total knee (TKR) replacement for idiopathic osteoarthritis (OA) at a major centre, we determined the prevalence of these replacements for idiopathic OA in their 1171 siblings and 376 spouses. Using spouses as controls, the relative risk of THR in siblings was 1.86 (95% CI 0.93 to 3.69). The relative risk for TKR in siblings v spouses was 4.8 (95 % CI 0.64 to 36.4) whereas the risk for the combined outcome measure of THR or TKR was 2.32 (95% CI 1.22 to 4.43) when siblings and spouses over 64 years of age were compared. Using a threshold liability model (Falconer), the heritability of end-stage OA of the hip was estimated at 27%. The increased risks of joint replacement for severe, idiopathic OA which we found in siblings suggest that genetic influences are important in end-stage OA of the hip and knee.
在一个主要中心，我们对402例因特发性骨关节炎（OA）接受全髋关节置换术（THR）或全膝关节置换术（TKR）的患者进行了一项前瞻性横断面调查，确定了其1171名兄弟姐妹和376名配偶中因特发性OA进行这些置换术的患病率。以配偶作为对照，兄弟姐妹中进行THR的相对风险为1.86（95%可信区间0.93至3.69）。兄弟姐妹与配偶相比，TKR的相对风险为4.8（95%可信区间0.64至36.4），而当比较64岁以上的兄弟姐妹和配偶时，THR或TKR联合结局指标的风险为2.32（95%可信区间1.22至4.43）。使用阈值易感性模型（Falconer法），估计髋关节终末期OA的遗传度为27%。我们在兄弟姐妹中发现的严重特发性OA关节置换风险增加表明，遗传因素在髋关节和膝关节终末期OA中很重要。
