Brizard F, Dreyfus B, Guilhot F, Tanzer J, Brizard A
Department of Hematology and Medical Oncology, University Hospital, Poitiers, France.
Leuk Lymphoma. 1997 May;25(5-6):539-43. doi: 10.3109/10428199709039042.
Translocation t(11;14)(q13;q32) and/or 11q13 rearrangements have been reported in various B cell immunoproliferative disorders. They appear to be frequent in mantle cell zone lymphoma (MZL) and rare in B-cell chronic lymphocytic leukemia (B-CLL). Discrimination between MZL and B-CLL is sometimes uncertain on the basis of morphology and immunophenotype. To evaluate the incidence of 11q13 rearrangements in B-CLL, purified B cells from 59 untreated patients were studied by cytogenetic methods after short term stimulated culture. Abnormalities at band 11q13 were found in 2 cases only. Fluorescent in situ hybridization (FISH) study confirmed del(11)(q13) in one case and showed translocation t(11;13) in another one. Thus this rearrangement appears to be very rare in B-CLL and its finding should lead to a careful search for the characteristic features of MZL, namely, morphology, the expression of CD5 without CD23, high density monotypic SIg, together with t(11;14) and/or bcl-1/IgH rearrangement.
在各种B细胞免疫增殖性疾病中均有11号染色体与14号染色体易位t(11;14)(q13;q32)和/或11q13重排的报道。它们在套细胞淋巴瘤（MZL）中似乎很常见，而在B细胞慢性淋巴细胞白血病（B-CLL）中则很罕见。基于形态学和免疫表型，有时难以区分MZL和B-CLL。为了评估11q13重排在B-CLL中的发生率，对59例未经治疗患者的纯化B细胞在短期刺激培养后采用细胞遗传学方法进行研究。仅在2例中发现11q13带异常。荧光原位杂交（FISH）研究证实1例存在11号染色体长臂缺失del(11)(q13)，另1例显示11号与13号染色体易位t(11;13)。因此，这种重排在B-CLL中似乎非常罕见，其发现应促使仔细寻找MZL的特征性表现，即形态学、无CD23的CD5表达、高密度单克隆表面免疫球蛋白（SIg），以及t(11;14)和/或bcl-1/IgH重排。
