血清样本中麦角酸二乙酰胺（LSD）的气相色谱/质谱测定法。
Gas chromatographic/mass spectrometric determination of lysergic acid diethylamide (LSD) in serum samples.
作者信息
Musshoff F, Daldrup T
机构信息
Institute of Legal Medicine, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.
出版信息
Forensic Sci Int. 1997 Aug 4;88(2):133-40. doi: 10.1016/s0379-0738(97)00063-7.
A sensitive method for the detection and quantification of lysergic acid diethylamide (LSD) in serum samples is described. After liquid-liquid extraction the trimethylsilyl derivative of LSD is detected by gas chromatography-mass spectrometry. Experiments with spiked samples resulted in a recovery of 76%, the coefficient of variation was 9.3%. Excellent linearity was obtained over the range 0.1-10 ng ml-1. Additionally experiments demonstrating the light sensitivity of LSD are presented together with casuistics.
本文描述了一种用于检测和定量血清样本中麦角酸二乙酰胺（LSD）的灵敏方法。液液萃取后，通过气相色谱 - 质谱法检测LSD的三甲基硅烷基衍生物。加标样品实验的回收率为76%，变异系数为9.3%。在0.1 - 10 ng/ml范围内获得了良好的线性关系。此外，还介绍了证明LSD对光敏感的实验以及病例。
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