Gupta A, Sinha R S
Safdarjang Hospital, New Delhi.
J Assoc Physicians India. 1996 Aug;44(8):546, 551-3.
Forty four patients (22 of overt hypothyroidism and 22 of subclinical hypothyroidism) and 11 controls underwent lipid profile evaluation and two dimensional echocardiography. Amongst the various parameters evaluated, mean Interventricular Septal (IVS) dimensions were significantly (p < 0.005) raised in overt hypothyroidism [IVS: end diastolic (ED) = 0.973 +/- 0.223 cm.; end systolic (ES) = 1.300 +/- 0.240 cm.] with respect to control group [IVS : ED = 0.747 +/- 0.118 cm.; ES = 1.073 +/- 0.173 cm.]. Mean Left Ventricular Posterior Wall (LVPW) thickness was also significantly (p < 0.005) raised in overt hypothyroidism [LVPW : ED = 0.944 +/- 0.200 cm.; ES = 1.350 +/- 0.243 cm.] in comparison with control group [LVPW : ED = 0.779 +/- 0.091 cm.; ES = 1.176 +/- 0.128 cm.]. Evidence of diastolic dysfunction was present in both subclinical (n = 2) and overt hypothyroidism (n = 6) while pericardial effusion was seen only in overt hypothyroidism (n = 10). Mean Serum cholesterol was significantly raised in both subclinical (192.13 +/- 47.40 mg%) (p < 0.05) and overt hypothyroidism (231.27 +/- 68.30 mg%) (p < 0.005) with respect to control group (157.63 +/- 37.69 mg%). In overt hypothyroid patients mean serum Triglyceride (235.59 +/- 137.53 mg%) (p < 0.05), LDL (126.09 +/- 54.99 mg%) (p < 0.05) and Apo-B (0.698 +/- 0.354 g/L) (p < 0.05) levels were significantly higher as compared to control group (serum triglyceride 165.45 +/- 49.15 mg%, LDL 88.72 +/- 38.75 mg%, Apo-B 0.474 +/- 0.176 g/L.
44例患者（22例显性甲状腺功能减退和22例亚临床甲状腺功能减退）及11名对照者接受了血脂谱评估和二维超声心动图检查。在评估的各项参数中，显性甲状腺功能减退患者的平均室间隔（IVS）尺寸显著升高（p<0.005）[IVS：舒张末期（ED）=0.973±0.223cm；收缩末期（ES）=1.300±0.240cm]，而对照组[IVS：ED = 0.747±0.118cm；ES = 1.073±0.173cm]。显性甲状腺功能减退患者的平均左心室后壁（LVPW）厚度也显著升高（p<0.005）[LVPW：ED = 0.944±0.200cm；ES = 1.350±0.243cm]，相比之下对照组[LVPW：ED = 0.779±0.091cm；ES = 1.176±0.128cm]。亚临床甲状腺功能减退（n = 2）和显性甲状腺功能减退（n = 6）均存在舒张功能障碍的证据，而心包积液仅见于显性甲状腺功能减退（n = 10）。亚临床甲状腺功能减退（192.13±47.40mg%）（p<0.05）和显性甲状腺功能减退（231.27±68.30mg%）（p<0.005）患者的平均血清胆固醇相对于对照组（157.63±37.69mg%）均显著升高。与对照组相比，显性甲状腺功能减退患者的平均血清甘油三酯（235.59±137.53mg%）（p<0.05）、低密度脂蛋白（LDL）（126.09±54.99mg%）（p<0.05）和载脂蛋白B（0.698±0.354g/L）（p<0.05）水平显著更高（对照组血清甘油三酯165.45±49.15mg%，LDL 88.72±38.75mg%，载脂蛋白B 0.474±0.176g/L）。
