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儿童脊髓肿瘤的治疗

Treatment of spinal cord tumors in children.

作者信息

Mottl H, Koutecky J

机构信息

Department of Pediatric Oncology, University Hospital, Prague, Czech Republic.

出版信息

Med Pediatr Oncol. 1997 Oct;29(4):293-5. doi: 10.1002/(sici)1096-911x(199710)29:4<293::aid-mpo10>3.0.co;2-c.

Abstract

BACKGROUND

A retrospective review was carried out of nine children under 17 years of age with a diagnosis of intramedullary tumor seen during the period 1989-1995. Six had astrocytomas; one each had an ependymoma, a PNET, and a choroid plexus papilloma. Five patients had back pain, 3 others had mild pareses and the ninth had incapacitating defects. Seven of the 9 were treated by subtotal extirpation of the lesion, and biopsy alone was performed in the other two. All tumors were low grade (grade I or II) and therefore radiation therapy (RT) was performed as the only postoperative treatment in 8 of the 9 children.

RESULTS

In February 1996, seven (77.8%) children were alive and two (22.2%) died of recurrent tumor (7 months and 5 years after diagnosis, respectively). Median follow-up was 3 years 4 months (range: 1 year 6 months to 7 years 3 months).

CONCLUSION

Surgical removal of intraspinal tumors provides the best hope of control, but spinal column deformity after laminectomy and irradiation is a serious long-term problem in children. Orthopedic supervision for the prevention of these deformities; e.g., by external immobilization, is mandatory.

摘要

背景

对1989年至1995年期间确诊的9名17岁以下髓内肿瘤患儿进行了回顾性研究。其中6例为星形细胞瘤;1例为室管膜瘤、1例为原始神经外胚层肿瘤(PNET)、1例为脉络丛乳头状瘤。5例患者有背痛,另外3例有轻度轻瘫,第9例有严重功能障碍。9例中有7例接受了病变次全切除治疗,另外2例仅进行了活检。所有肿瘤均为低级别(I级或II级),因此9例患儿中有8例术后仅接受了放射治疗(RT)。

结果

1996年2月,7名(77.8%)患儿存活,2名(22.2%)死于肿瘤复发(分别在诊断后7个月和5年)。中位随访时间为3年4个月(范围:1年6个月至7年3个月)。

结论

手术切除脊柱内肿瘤是控制病情的最大希望,但椎板切除术后脊柱畸形以及放疗是儿童严重的长期问题。必须进行骨科监护以预防这些畸形,例如通过外部固定。

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