Yamane H, Nakagawa T, Iguchi H, Shibata S, Takayama M, Sunami K, Nakai Y
Department of Otolaryngology, Osaka City University Medical School, Japan.
Auris Nasus Larynx. 1997 Jul;24(3):221-5. doi: 10.1016/s0385-8146(97)00042-4.
We performed an in vitro study in order to determine possible triggers of hair cell regeneration in the chick basilar papilla following degeneration. We compared the response of sensory epithelium damaged by collagenase treatment with that damaged by acoustic trauma. The former exhibited no proliferative activity, but the latter did. The basilar papillae damaged by acoustic trauma could have proliferating activity in medium containing fetal bovine serum (FBS) or epidermal growth factor (EGF) but not in the medium without FBS or EGF. These findings indicate that regeneration of basilar papillae depends on the manner of cell death and that FBS or EGF is required for regeneration.
我们进行了一项体外研究，以确定雏鸡基底乳头变性后毛细胞再生的可能触发因素。我们比较了胶原酶处理损伤的感觉上皮与声损伤损伤的感觉上皮的反应。前者没有增殖活性，而后者有。经声损伤的基底乳头在含有胎牛血清（FBS）或表皮生长因子（EGF）的培养基中可有增殖活性，但在不含FBS或EGF的培养基中则没有。这些发现表明基底乳头的再生取决于细胞死亡的方式，并且再生需要FBS或EGF。
