Hucker H B, Stauffer S C, Albert K S, Lei B W
J Clin Pharmacol. 1977 Nov-Dec;17(11-12):719-27. doi: 10.1002/j.1552-4604.1977.tb01547.x.
Cyclobenzaprine was extensively metabolized in man, less than 1% of the dose being excreted unchanged in the urine. Comparison of areas under plasma level curves (AUC) after oral and intravenous doses suggests that the drug may be partly metabolized in the lumen or during its first passage through the gut wall and/or liver. Average plasma levels of the drug increased with increasing dosage, but the AUC increased less rapidly with increasing dose, possibly because of dose-dependent absorption.
环苯扎林在人体内被广泛代谢，尿液中以原形排出的剂量不到1%。口服和静脉给药后血浆水平曲线下面积（AUC）的比较表明，该药物可能在肠腔内或首次通过肠壁和/或肝脏时部分被代谢。药物的平均血浆水平随剂量增加而升高，但AUC随剂量增加的升高速度较慢，这可能是由于剂量依赖性吸收所致。
