Suárez M, Perassi N
Instituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.
Life Sci. 1995;56(3):163-7.
The effects of chronic stress (forced immobilization, 15 min/day during 12 days), on the plasma corticosterone and the adrenal catecholamines response in rats with anterodorsal thalami nuclei (ADTN) lesions were studied. In sham lesioned rats, chronic stress produced a significant increase in plasma corticosterone (C), as compared to unstressed animals (p < 0.05). The adrenal C was, however, similar in both groups. There were no differences in plasma C values between unstressed and stressed lesioned rats. The adrenal C content, was significantly lower (P < 0.005) in stressed lesioned rats when compared with unstressed lesioned animals. Adrenal norepinephrine (NE) values, in sham lesioned rats after forced immobilization, were significantly below those found in unstressed sham lesioned ones (P < 0.05). There were no changes in adrenal epinephrine (E) response after forced immobilization. In lesioned rats, NE response to chronic stress showed the opposite pattern to that in sham lesioned ones; the adrenal glands of these animals showed a significant increase in NE content as compared to unstressed lesioned rats (P < 0.01). Similar alterations in the adrenal E concentration were found, post stress values were significantly higher (P < 0.01).
研究了慢性应激（强迫固定，每天15分钟，持续12天）对丘脑前背核（ADTN）损伤大鼠血浆皮质酮和肾上腺儿茶酚胺反应的影响。在假损伤大鼠中，与未应激动物相比，慢性应激使血浆皮质酮（C）显著增加（p<0.05）。然而，两组动物的肾上腺C相似。未应激和应激损伤大鼠的血浆C值无差异。与未应激损伤动物相比，应激损伤大鼠的肾上腺C含量显著降低（P<0.005）。在强迫固定后，假损伤大鼠的肾上腺去甲肾上腺素（NE）值显著低于未应激假损伤大鼠（P<0.05）。强迫固定后肾上腺肾上腺素（E）反应无变化。在损伤大鼠中，NE对慢性应激的反应与假损伤大鼠相反；与未应激损伤大鼠相比，这些动物的肾上腺NE含量显著增加（P<0.01）。肾上腺E浓度也有类似变化，应激后值显著更高（P<0.01）。
