Fiore M, Moroni R, Aloe L
Institute of Neurobiology, CNR, Rome, Italy.
Physiol Behav. 1997 Aug;62(2):399-406. doi: 10.1016/s0031-9384(97)00036-x.
In this study, CD-1 female mice, deprived of the submaxillary salivary glands, were infected with S. mansoni and their behavior was observed 15 weeks after infection, when the eggs of the parasite are present in the brain. Sialectomized infected mice showed changes in exploratory activity, sniffing, and wall-rearing in the open-field and in the black/white box, but no differences in pain sensitivity were observed on the hot plate. The present results suggest that the modifications in the behavior of sialectomized infected mice might be associated with the inability of the animals to cope with the aversive effects of the infection and, most probably, with modifications in the levels of polypeptides released into the bloodstream by the salivary glands, affecting the NGF-responsive cells of the nervous, endocrine, and immune systems.
在本研究中，摘除了下颌下唾液腺的CD-1雌性小鼠感染了曼氏血吸虫，并在感染15周后观察其行为，此时寄生虫卵存在于大脑中。唾液腺切除的感染小鼠在旷场和黑白箱试验中，探索活动、嗅探和靠墙站立行为发生了变化，但在热板试验中未观察到疼痛敏感性的差异。目前的结果表明，唾液腺切除的感染小鼠行为的改变可能与动物无法应对感染的厌恶效应有关，很可能还与唾液腺释放到血液中的多肽水平变化有关，这些变化影响了神经、内分泌和免疫系统中对神经生长因子（NGF）有反应的细胞。
