Aloe L, Moroni R, Angelucci F
Institute of Neurobiology, Rome, Italy.
Arch Oral Biol. 1996 Jan;41(1):21-6. doi: 10.1016/0003-9969(95)00101-8.
Mice infected with Schistosoma mansoni were used to investigate the role of the submaxillary salivary gland and nerve growth factor (NGF) in temperature response. The results showed that the infection increased (36.5 +/- 0.3 vs 35.7 +/- 0.2), while sialoadenectomy decreased (34.4 +/- 0.2 vs 35.1 +/- 0.2) body temperature. These temperature changes were associated with high or low circulating NGF levels, respectively. It was also found that infection altered the distribution of oxytocin-positive neurones in the hypothalamus and that administration of 20 mu g of purified NGF in normal mice raised (36.1 +/- 0.2 vs 35.1 +/- 0.2) and of NGF antibodies decreased (34.0 +/- 0.2 vs 35.1 +/- 0.2) body temperature. Taken together, these observations suggest that salivary NGF influences the temperature set-point in adult rodents, but the mechanism regulating these events remains to be elucidated.
感染曼氏血吸虫的小鼠被用于研究颌下唾液腺和神经生长因子（NGF）在体温反应中的作用。结果显示，感染使体温升高（36.5±0.3对35.7±0.2），而唾液腺切除则使体温降低（34.4±0.2对35.1±0.2）。这些体温变化分别与循环中NGF水平的高低相关。还发现感染改变了下丘脑催产素阳性神经元的分布，并且在正常小鼠中注射20μg纯化的NGF会使体温升高（36.1±0.2对35.1±0.2），而注射NGF抗体则会使体温降低（34.0±0.2对35.1±0.2）。综上所述，这些观察结果表明唾液NGF会影响成年啮齿动物的体温设定点，但调节这些事件的机制仍有待阐明。
