Suppression of Francisella tularensis growth in the rat by co-infection with F. novicida.
作者信息
Cowley S C, Myltseva S V, Nano F E
机构信息
Department of Biochemistry and Microbiology, University of Victoria, B.C., Canada.
出版信息
FEMS Microbiol Lett. 1997 Aug 1;153(1):71-4. doi: 10.1111/j.1574-6968.1997.tb10465.x.
Abstract
We have previously shown that when cultured in vitro, peritoneal rat macrophages infected with Francisella novicida spontaneously release nitric oxide in sufficient quantities to inhibit bacterial growth. However, it is not known whether F. novicida can have a similar antimicrobial effect in vivo. Here we show that a co-infection of F. novicida with Francisella tularensis can suppress the number of F. tularensis cells in rat spleens by as much as 100-fold.
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