Gebel T, Christensen S, Dunkelberg H
Medical Institute of General Hygiene and Environmental Health, University of Goettingen, Germany.
Anticancer Res. 1997 Jul-Aug;17(4A):2603-7.
Antimony and arsenic compounds are known to have a genotoxic potential. Soil contamination with these elements can be due to the presence of natural ore sources of fahlore (gray copper). As a result, human and animal populations may be highly exposed. The sister chromatid exchange (SCE) test is an adequate tool for the sensitive detection of antimony and arsenic genotoxicity. We used this assay to investigate the coergism of the two elements in vitro to gain data for the assessment of a putative risk from coexposure. The combinative effect of antimony and arsenic in the SCE test appeared subadditive. Additionally, the SCE served to determine the genotoxic potential in extracts of contaminated fahlore soil samples gained under mildly acidic conditions. The genotoxicity observed was very low because antimony and arsenic predominated in the pentavalent, non-genotoxic state, but, the partial antagonism observed in the in vitro experiments could be an additional explanation for the low genotoxicity.
已知锑和砷化合物具有遗传毒性潜力。这些元素对土壤的污染可能源于辉铜矿（灰铜矿）等天然矿源的存在。因此，人类和动物种群可能会受到高度暴露。姐妹染色单体交换（SCE）试验是灵敏检测锑和砷遗传毒性的合适工具。我们使用该试验来研究这两种元素在体外的协同作用，以获取数据用于评估共同暴露的潜在风险。锑和砷在SCE试验中的联合效应表现为亚相加性。此外，SCE用于确定在轻度酸性条件下获得的受污染辉铜矿土壤样品提取物中的遗传毒性潜力。观察到的遗传毒性非常低，因为锑和砷主要处于五价、无遗传毒性的状态，但是，在体外实验中观察到的部分拮抗作用可能是遗传毒性低的另一种解释。
