乳腺癌患者血清中循环细胞间黏附分子-1的水平。

Serum levels of circulating intercellular adhesion molecule-1 in patients with breast cancer.

作者信息

Sheen-Chen S M, Eng H L, Sheen C W, Cheng Y F, Chou F F, Chen W J

机构信息

Department of Surgery, Pathology and Diagnostic Radiology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, R.O.C.

出版信息

Anticancer Res. 1997 Jul-Aug;17(4A):2823-6.

PMID:9252723

Abstract

BACKGROUND

The outcome of breast cancer is usually determined by multiple factors. Circulating intercellular adhesion molecule-1 has been found to be increased in the circulation of patients with malignancy. This study was designed with the aim of evaluating the prognostic significance of circulating intercellular adhesion molecule-1 in breast cancer.

METHODS AND MATERIAL

From December 1994 to May 1995, 50 patients with invasive breast carcinoma were included. Venous blood samples were collected before surgery and the serum levels of circulating intercellular adhesion molecule-1 were measured with an enzyme immunoassay method. The data of maximum tumor size, age, estrogen receptor status, lymph node status and TNM staging were collected and evaluated simultaneously with the serum levels of circulating intercellular adhesion molecule-1. Fifteen healthy subjects were used as control group.

RESULTS

The mean value of circulating intercellular adhesion molecule-1 in patient group was 463 +/- 92 ng/ml and that of the control group was 346 +/- 68 ng/ml and the difference was significant (p < 0.01). In univariable analysis, patients with maximum tumor size of 5 cm or greater (p < 0.01), more advanced lymph node status (p < 0.01) and more advanced TNM staging (p < 0.01) were shown to have significantly higher serum levels of circulating intercellular adhesion molecule-1. However, in multivariable analysis, TNM staging was demonstrated to be the only independent factor (p < 0.01) related to significant, higher serum level of circulating intercellular adhesion molecule-1.

CONCLUSION

Preoperative serum levels of circulating intercellular adhesion molecule-1 may reflect the severity of staging for invasive breast cancer and may be a promising, additive predictor which deserves further investigation.

摘要

背景

乳腺癌的预后通常由多种因素决定。已发现恶性肿瘤患者循环中的细胞间黏附分子-1水平升高。本研究旨在评估循环细胞间黏附分子-1在乳腺癌中的预后意义。

方法与材料

1994年12月至1995年5月，纳入50例浸润性乳腺癌患者。术前采集静脉血样本，采用酶免疫测定法检测循环细胞间黏附分子-1的血清水平。同时收集并评估最大肿瘤大小、年龄、雌激素受体状态、淋巴结状态和TNM分期的数据以及循环细胞间黏附分子-1的血清水平。15名健康受试者作为对照组。

结果

患者组循环细胞间黏附分子-1的平均值为463±92 ng/ml，对照组为346±68 ng/ml，差异有统计学意义（p<0.01）。单因素分析显示，最大肿瘤大小为5 cm或更大（p<0.01）、淋巴结状态更晚（p<0.01）以及TNM分期更晚（p<0.01）的患者循环细胞间黏附分子-1的血清水平显著更高。然而，多因素分析表明，TNM分期是与循环细胞间黏附分子-1血清水平显著升高相关的唯一独立因素（p<0.01）。