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评估原发性乳腺癌女性血清中细胞黏附分子sVCAM - 1和sICAM - 1浓度的临床实用性。

The clinical usefulness of assessing the concentration of cell adhesion molecules sVCAM-1 and sICAM-1 in the serum of women with primary breast cancer.

作者信息

Thielemann Anna, Baszczuk Aleksandra, Kopczyński Zygmunt, Nowak Adrianna, Grodecka-Gazdecka Sylwia

机构信息

Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Poland.

Department of Oncology, Poznan University of Medical Sciences, Poland.

出版信息

Contemp Oncol (Pozn). 2014;18(4):252-9. doi: 10.5114/wo.2014.43492. Epub 2014 Aug 30.

DOI:10.5114/wo.2014.43492
PMID:25258583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4171471/
Abstract

AIM OF THE STUDY

Assessment of the concentrations of the soluble forms of the cell adhesion molecules sVCAM-1 and sICAM-1 in serum of female breast cancer patients. These concentrations were assessed in relation to factors such as: age, clinical stage of disease, histological grade of malignancy, the status of the local axillary lymph nodes, and the size of the primary tumour.

MATERIAL AND METHODS

A total of 103 patients with primary breast cancer, aged 29 to 89 years, were investigated. The control group consisted of 40 healthy women. The concentration of sVCAM-1 and sICAM-1 was assessed using an enzyme-linked immunosorbent assay (ELISA).

RESULTS

The results of the study suggest that the level of sVCAM-1 and sICAM-1 in the serum of women with breast cancer was significantly higher than that seen in the serum of healthy women. A relationship between the level of adhesion molecules and the stage of clinical disease advancement was discovered. There was a correlation between the increasing concentrations of sVCAM-1 and sICAM-1 and with the aggressiveness of the disease. Significant differences were also found in the group of women with metastases to the axillary lymph nodes and women with no metastasis. Similar correlations were found between sVCAM-1 and sICAM-1 levels and the size of primary tumour.

CONCLUSIONS

The results obtained suggest that the assessment of the soluble forms of sVCAM-1 and sICAM-1 may be useful indicators in the assessment of the clinical advancement of breast cancer.

摘要

研究目的

评估女性乳腺癌患者血清中细胞黏附分子可溶性形式sVCAM - 1和sICAM - 1的浓度。这些浓度根据年龄、疾病临床分期、恶性组织学分级、腋窝局部淋巴结状态以及原发肿瘤大小等因素进行评估。

材料与方法

共调查了103例年龄在29至89岁之间的原发性乳腺癌患者。对照组由40名健康女性组成。采用酶联免疫吸附测定法（ELISA）评估sVCAM - 1和sICAM - 1的浓度。

结果

研究结果表明，乳腺癌女性血清中sVCAM - 1和sICAM - 1的水平显著高于健康女性血清中的水平。发现黏附分子水平与临床疾病进展阶段之间存在关联。sVCAM - 1和sICAM - 1浓度的增加与疾病的侵袭性之间存在相关性。在有腋窝淋巴结转移的女性组和无转移的女性组中也发现了显著差异。sVCAM - 1和sICAM - 1水平与原发肿瘤大小之间也发现了类似的相关性。

结论

获得的结果表明，评估sVCAM - 1和sICAM - 1的可溶性形式可能是评估乳腺癌临床进展的有用指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c59/4171471/78860b8906af/WO-18-22908-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c59/4171471/dd0aef15f914/WO-18-22908-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c59/4171471/703e4b6ee4e0/WO-18-22908-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c59/4171471/e210fe811498/WO-18-22908-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c59/4171471/3b161f055058/WO-18-22908-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c59/4171471/345d381a4f2a/WO-18-22908-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c59/4171471/ab0541342e6c/WO-18-22908-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c59/4171471/a463aa2c86e8/WO-18-22908-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c59/4171471/78860b8906af/WO-18-22908-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c59/4171471/dd0aef15f914/WO-18-22908-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c59/4171471/703e4b6ee4e0/WO-18-22908-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c59/4171471/e210fe811498/WO-18-22908-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c59/4171471/3b161f055058/WO-18-22908-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c59/4171471/345d381a4f2a/WO-18-22908-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c59/4171471/ab0541342e6c/WO-18-22908-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c59/4171471/a463aa2c86e8/WO-18-22908-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c59/4171471/78860b8906af/WO-18-22908-g008.jpg

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