Ricci M, Matucci A, Rossi O
Institute of Internal Medicine and Immunoallergology, University of Florence, Italy.
J Investig Allergol Clin Immunol. 1997 May-Jun;7(3):144-50.
In the last years Th2-like cells, able to produce IL-4, IL-5, IL-6 and IL-10, have been shown to play an important role in the pathogenesis of allergic diseases. They are absolutely required for IgE production by B-cells and are expanded at the level of target tissues of atopic patients. Very recently, much attention has been focused on the genetic and environmental factors responsible for the differentiation and ongoing expansion of allergen-specific Th2-like cells in atopic subjects. In this review possible cellular sources of IL-4 in the primary, secondary and ongoing responses to allergens are discussed. In atopics, Th cell precursors themselves could be proposed as a main source of IL-4 in the primary responses to allergens. However, there is extensive evidence for the role of other cells such as mast cells, basophils and eosinophils as important sources of IL-4 the secondary and ongoing responses to allergens.
在过去几年中，能够产生白细胞介素-4（IL-4）、白细胞介素-5（IL-5）、白细胞介素-6（IL-6）和白细胞介素-10（IL-10）的Th2样细胞已被证明在过敏性疾病的发病机制中起重要作用。它们对于B细胞产生IgE绝对必要，并且在特应性患者的靶组织水平上扩增。最近，人们将大量注意力集中在负责特应性个体中过敏原特异性Th2样细胞分化和持续扩增的遗传和环境因素上。在这篇综述中，讨论了在对过敏原的初次、二次和持续反应中IL-4可能的细胞来源。在特应性个体中，Th细胞前体本身可被认为是对过敏原初次反应中IL-4的主要来源。然而，有大量证据表明其他细胞如肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞在对过敏原的二次和持续反应中作为IL-4的重要来源发挥作用。
