de Barrio M, Tornero P, Prieto A, Sainza T, Zubeldia J M, Herrero T
Sección de Alergia, Hospital General Gregorio Marañón, Madrid, Spain.
J Investig Allergol Clin Immunol. 1997 May-Jun;7(3):193-4.
Citiolone (N-acetylhomocysteinethiolactone) is a thiolic-derived medication frequently used in Spain and in other countries as a mucolytic agent for the treatment of certain hepatic disorders. Mucolytic drugs have rarely been implicated in the fixed drug eruption etiology. We report on a patient who presented several episodes of fixed exanthema related to citiolone intake. The patch test with citiolone (10% in dimethyl sulfoxide) was negative. The diagnosis was confirmed by a positive controlled oral challenge test. Other mucolytic thiolic-derivatives (N-acetylcysteine) were tolerated by the patient, thus crossreactivity between these drugs seems to be unlikely.
西替洛酮（N - 乙酰高半胱氨酸硫内酯）是一种硫醇衍生药物，在西班牙和其他国家常用于作为黏液溶解剂治疗某些肝脏疾病。黏液溶解药物很少与固定性药疹的病因有关。我们报告了一名患者，该患者出现了几次与服用西替洛酮相关的固定性皮疹发作。用西替洛酮（在二甲基亚砜中10%）进行的斑贴试验为阴性。通过阳性对照口服激发试验确诊。患者对其他硫醇衍生的黏液溶解剂（N - 乙酰半胱氨酸）耐受，因此这些药物之间似乎不太可能发生交叉反应。
