Kanemura T, Kawakami N, Deguchi M, Mimatsu K, Iwata H
Department of Orthopaedic Surgery, Nagoya University School of Medicine, Japan.
Spine (Phila Pa 1976). 1997 Jul 15;22(14):1563-7. doi: 10.1097/00007632-199707150-00006.
Pinealectomy induces experimental scoliosis in chickens. This study analyzed the natural course and characteristics of the scoliosis that developed after pinealectomy.
To investigate the natural course of experimental scoliosis after pinealectomy in chickens and determine its similarity to idiopathic scoliosis in humans. SUMMARY OF BACKGROUND DATA. Pinealectomy affects the systemic hormonal balance and consistently induces progressive scoliosis in chickens.
Thirty five chickens were divided into two groups, a pinealectomy group (n = 25) and a control group (n = 10). At the age of 3 days, all chickens in the pinealectomy group underwent surgery. Spinal radiographs of all chickens were taken at 2-week intervals until the age of 16 weeks.
There was no alteration of spinal alignment in the control group. Seventeen chickens in the pinealectomy group had scoliosis (17 degrees-85 degrees) that featured a three-dimensional spinal deformity consisting of both lateral curvature and vertebral rotation with rib humps. The scoliosis progressed to become slight, moderate, or severe as the chickens grew older. Pinealectomized chickens showed several other differences from chickens of the normal control group, such as poor weight gain, underdeveloped cockscombs, and late onset of egg laying.
The scoliosis developing in chickens after pinealectomy was similar to human idiopathic scoliosis, and thus seems to be a useful model of idiopathic scoliosis.
松果体切除可诱发鸡的实验性脊柱侧凸。本研究分析了松果体切除后所发生脊柱侧凸的自然病程及特点。
探讨鸡松果体切除后实验性脊柱侧凸的自然病程，并确定其与人类特发性脊柱侧凸的相似性。背景资料总结：松果体切除会影响全身激素平衡，并持续诱发鸡的进行性脊柱侧凸。
35只鸡被分为两组，松果体切除组（n = 25）和对照组（n = 10）。3日龄时，松果体切除组的所有鸡均接受手术。所有鸡每隔2周拍摄脊柱X线片，直至16周龄。
对照组脊柱排列无改变。松果体切除组17只鸡出现脊柱侧凸（17度 - 85度），其特征为三维脊柱畸形，包括侧方弯曲、椎体旋转及肋骨隆起。随着鸡龄增长，脊柱侧凸逐渐发展为轻度、中度或重度。松果体切除的鸡与正常对照组鸡还存在其他一些差异，如体重增加缓慢、鸡冠发育不良及产蛋开始较晚。
鸡松果体切除后发生的脊柱侧凸与人类特发性脊柱侧凸相似，因此似乎是特发性脊柱侧凸的一个有用模型。
