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TFIIIA N 端锌指结构域在 DNA 复合物中的结构组装与动力学

Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA.

作者信息

Foster M P, Wuttke D S, Radhakrishnan I, Case D A, Gottesfeld J M, Wright P E

出版信息

Nat Struct Biol. 1997 Aug;4(8):605-8. doi: 10.1038/nsb0897-605.

DOI:10.1038/nsb0897-605
PMID:9253405
Abstract

The three N-terminal zinc fingers of transcription factor IIIA bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered.

摘要

转录因子IIIA的三个N端锌指结合在DNA大沟中。相邻锌指之间形成了大量的堆积界面，连接子在结合DNA后失去了其固有的灵活性，并且几个与DNA识别有关的赖氨酸侧链呈动态无序状态。

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