Chagnon Y C, Pérusse L, Bouchard C
Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Québec, Canada.
Curr Opin Lipidol. 1997 Aug;8(4):205-11. doi: 10.1097/00041433-199708000-00003.
This brief review covers the findings reported in 1996 and in the first 2 months of 1997 on the genetic epidemiology and the molecular markers of human obesity. Although relatively little new evidence has been published on the heritability and other genetic epidemiology characteristics of obesity and fat topography, more has been reported on candidate genes, positional candidate genes and quantitative trait loci. Two recent genome-wide scans have revealed that several molecular markers on different chromosomes were linked to obesity-related phenotypes. Little support for a role for specific candidate genes can be found at this time. A large number of rodent quantitative trait loci have been uncovered so far but they have not yet been systematically tested in human populations.
本简要综述涵盖了1996年及1997年头两个月所报道的关于人类肥胖的遗传流行病学和分子标记的研究结果。尽管关于肥胖及其脂肪分布的遗传度和其他遗传流行病学特征的新证据相对较少，但关于候选基因、定位候选基因和数量性状位点的报道较多。最近的两项全基因组扫描显示，不同染色体上的几个分子标记与肥胖相关表型有关联。目前尚未发现特定候选基因发挥作用的有力证据。迄今为止，已经发现了大量啮齿动物数量性状位点，但尚未在人群中进行系统测试。
