Lentschener C, Benhamou D
Department of Anaesthesiology, Hôpital Antoine Béclère, Université Paris Sud, Clamart, France.
Eur J Anaesthesiol. 1997 Jul;14(4):385-8. doi: 10.1046/j.1365-2346.1997.00146.x.
Forty-three ASA Grade I patients scheduled for elective abdominal surgery received at random either 25% or 50% inspired oxygen for intra-operative mechanical ventilation lasting 4-6 h. Pulse oximetry was monitored continuously. Venous admixture was assessed from the PaO2/FIO2 ratio and was measured twice intraoperatively: at the time of incision, and during surgical wound closure. PaO2 was measured 1 h after extubation having breathed room air for 10 min, if tolerated. The patients in the two groups were similar in regard to general characteristics, and had similar operations. Patients given oxygen 50% had operations that lasted longer, which made the trial more sensitive. The inspired oxygen did not affect pulmonary gas exchange either within each group or between groups under the conditions of the study. In no patient did pulse oximetry record an oxygen saturation below 95% intra-operatively.
43例计划接受择期腹部手术的ASA I级患者，在持续4 - 6小时的术中机械通气期间，随机接受25%或50%的吸入氧。持续监测脉搏血氧饱和度。通过动脉血氧分压/吸入氧分数值（PaO2/FIO2）评估静脉血掺杂情况，并在术中测量两次：切口时以及手术伤口缝合时。如果患者耐受，在拔管后呼吸室内空气10分钟时测量动脉血氧分压（PaO2）。两组患者的一般特征相似，手术也相似。接受50%氧气的患者手术持续时间更长，这使得试验更具敏感性。在本研究条件下，吸入氧在每组内或组间均未影响肺气体交换。术中没有患者的脉搏血氧饱和度记录低于95%。
