Hägermark O, Strandberg K, Hamberg M
J Invest Dermatol. 1977 Dec;69(6):527-30. doi: 10.1111/1523-1747.ep12687966.
The itch and erythematous responses induced by intradermal injection of prostaglandin E2 (PGE2), the unstable prostaglandin endoperoxide PGH2 (t1/2 approximately 5 min at 37 degrees C) and the stable endoperoxide analog (15S)-hydroxy-9alpha, 11alpha-(epoxymethano)prosta-5,13-dienoic acid (EPA) were studied in volunteers. The compounds were given alone or in combination with histamine. All the compounds produced flare reaction in the skin; the order of potency was PGE2 greater than PGH2 greater than EPA. PGE2 and PGH2 evoked a sensation of itch in about half of the subjects whereas the same doses of EPA gave no itch response. In combination with histamine all compounds elicited itch of longer duration and flare of larger area than could be accounted for by simple additive effects of any released histamine. The results indicate that the PGs and PG intermediates formed in skin may potentiate the pruritogenic and flare-inducing effects of inflammagens in man.
在志愿者中研究了皮内注射前列腺素E2（PGE2）、不稳定的前列腺素内过氧化物PGH2（37℃时半衰期约5分钟）和稳定的内过氧化物类似物（15S）-羟基-9α，11α-（环氧亚甲基）前列腺-5,13-二烯酸（EPA）所诱导的瘙痒和红斑反应。这些化合物单独给药或与组胺联合给药。所有化合物均在皮肤中产生风团反应；效力顺序为PGE2＞PGH2＞EPA。PGE2和PGH2在约一半的受试者中引起瘙痒感，而相同剂量的EPA未引起瘙痒反应。与组胺联合使用时，所有化合物引起的瘙痒持续时间更长，风团面积更大，这无法用任何释放的组胺的简单相加效应来解释。结果表明，皮肤中形成的PGs和PG中间体可能会增强人体内炎症介质的致痒和诱导风团的作用。
