泰国春武里府鲎中毒事件：临床、毒理学及治疗方面的考量

An outbreak of horseshoe crab poisoning in Chon Buri, Thailand: clinical, toxicologic and therapeutic considerations.

作者信息

Kanchanapongkul J, Kungsuwan A, Tantisiriwan V, Punthawangkun C, Krittayapoositpot P

机构信息

Department of Medicine, Chon Buri Hospital, Thailand.

出版信息

Southeast Asian J Trop Med Public Health. 1996 Dec;27(4):806-9.

PMID:9253889

Abstract

In 1994-1996, an outbreak of horseshoe crab poisoning by eating toxic eggs of the horseshoe crab Carcinoscorpius rotundicauda affected over 100 persons in Chon Buri which located on the eastern coast of Thailand. We discuss clinical description and management of this first major outbreak. The responsible toxin has been partially purified by means of ultrafiltration and high performance liquid chromatography. The horseshoe crab toxin is identified as tetrodotoxin (TTX) and anhydro TTX.

摘要

1994年至1996年，泰国东海岸春武里府发生了一起因食用圆尾鲎有毒卵导致的圆尾鲎中毒事件，100多人中毒。我们讨论了这起首次重大疫情的临床描述和处理情况。通过超滤和高效液相色谱法已对相关毒素进行了部分纯化。圆尾鲎毒素被鉴定为河豚毒素（TTX）和脱水河豚毒素。