Denninghoff K R, Smith M H, Chipman R A, Hillman L W, Jester P M, Hughes C E, Kuhn F, Rue L W
Department of Emergency Medicine, University of Alabama at Birmingham, USA.
J Trauma. 1997 Jul;43(1):29-34. doi: 10.1097/00005373-199707000-00009.
Noninvasive monitoring would likely improve trauma care. Using laser technology, we monitored the oxygen saturation in retinal vessels during exsanguination and hypoxia.
Seven anesthetized swine were bled at 0.4 mL/kg/min for 40 minutes. During exsanguination, retinal venous saturation (SrvO2) was measured using an eye oximeter, and central venous saturation (SvO2) was measured using a fiber-optic catheter. After the shed blood was reinfused, the FiO2 was progressively decreased from 0.97 to 0.07. Femoral artery oxygen saturation (SaO2) and retinal artery oxygen saturation (SraO2) were measured at each increment.
During exsanguination, SrvO2 correlated with blood loss (r = -0.93) and SvO2 (r = 0.94). SraO2 correlated with SaO2 during incremental hypoxia (R2 = 0.93 +/- 0.15).
In this model of exsanguination, retinal venous oxygen saturation correlates with blood volume and with central venous oxygen saturation. The SraO2 correlates with SaO2 during graded hypoxia. Use of an eye oximeter to noninvasively monitor trauma patients appears promising and warrants further study.
非侵入性监测可能会改善创伤护理。我们使用激光技术，在放血和缺氧过程中监测视网膜血管中的氧饱和度。
七只麻醉的猪以0.4 mL/kg/分钟的速度放血40分钟。放血过程中，使用眼血氧计测量视网膜静脉饱和度（SrvO2），并使用光纤导管测量中心静脉饱和度（SvO2）。回输失血后，将吸入氧分数（FiO2）从0.97逐渐降低至0.07。每次降低时测量股动脉血氧饱和度（SaO2）和视网膜动脉血氧饱和度（SraO2）。
放血过程中，SrvO2与失血量（r = -0.93）和SvO2（r = 0.94）相关。在逐渐缺氧过程中，SraO2与SaO2相关（R2 = 0.93 +/- 0.15）。
在这个放血模型中，视网膜静脉血氧饱和度与血容量和中心静脉血氧饱和度相关。在分级缺氧过程中，SraO2与SaO2相关。使用眼血氧计对创伤患者进行非侵入性监测似乎很有前景，值得进一步研究。
