Fitzsimmons T D, Fagerholm P, Wallin O
Department of Ophthalmology, St. Erik's Eye Hospital, Karolinska Institute, Stockholm, Sweden.
Acta Ophthalmol Scand. 1997 Jun;75(3):257-60. doi: 10.1111/j.1600-0420.1997.tb00768.x.
To histochemically analyze if the glycoseaminoglycan component of pseudoexfoliation material consists of hyaluronan.
The hyaluronan binding region of cartilage proteoglycans was utilized in a staining specific for hyaluronan. The technique has been described and employed previously. Human donor eyes with and without the presence of visible pseudoexfoliations were analyzed.
Hyaluronan was found to coat the fibrillar exfoliation material on the lens, the zonules, the iris epithelium and the ciliary body. It was also found on a capsular bag following cataract surgery.
In the anterior chamber hyaluronan constitutes one part of the exfoliation material. Abnormal findings of hyaluronan could be found in the cornea.
通过组织化学分析假性剥脱物质的糖胺聚糖成分是否由透明质酸组成。
利用软骨蛋白聚糖的透明质酸结合区域进行透明质酸特异性染色。该技术已在之前被描述和应用。对有和没有可见假性剥脱的人类供体眼进行分析。
发现透明质酸覆盖在晶状体、悬韧带、虹膜上皮和睫状体的纤维状剥脱物质上。在白内障手术后的囊袋中也发现了透明质酸。
在前房中，透明质酸是剥脱物质的一部分。在角膜中可发现透明质酸的异常表现。
