Dean G, Freestone M, van den Berg J P, Coenen J L
Medico-Social Research Board, Dublin, Ireland.
S Afr Med J. 1997 Jun;87(6):731-2.
Two sisters living in Holland, with a niece now living in South Africa, were reported in 1958 to have inherited intermittent acute porphyria (IAP). In 1994 both sisters died from primary liver cancer. Other reports have also noted an increased mortality from carcinoma of the liver in porphyrics. Porphyria variegata has a high prevalence in white and coloured South Africans, and it would be relatively easy to ascertain whether those who have inherited the gene for this disorder, in South Africa, have a higher than reported mortality from liver cancer. If they do, consideration should be given to ways to reduce their risk of developing and dying from this cancer.
据报道，1958年，居住在荷兰的两姐妹患有遗传性间歇性急性卟啉病（IAP），她们有一个侄女现居住在南非。1994年，这两姐妹均死于原发性肝癌。其他报告也指出，卟啉病患者的肝癌死亡率有所上升。杂色卟啉病在南非白人和有色人种中发病率很高，要确定南非那些遗传了这种疾病基因的人患肝癌的死亡率是否高于报道的死亡率相对容易。如果确实如此，就应该考虑采取措施降低他们患这种癌症以及死于这种癌症的风险。
