Moloney J R
J Laryngol Otol. 1977 Oct;91(10):837-46. doi: 10.1017/s0022215100084450.
In a retrospective study of 445 patients with nasal polyps, 95 (21 per cent) had asthma. Forty-two (44 per cent) of the patients with asthma had been skin tested and 27 (60 per cent) had positive reactions. Nasal polyps were twice as common in men as women, though a woman with nasal polyps was twice as likely to have asthma as a man. The average age of onset of polyps was 39 years and of asthma was 38 years. No significant difference was found in the age of onset of polyps or asthma in various groups of patients. Two per cent of all the patients in the series had nasal polyps, asthma and hypersensitivity to aspirin (the ASA triad). Ten per cent of those with polyps and asthma were hypersensitive to aspirin and thus had the full triad. Overall, 6 per cent of all the patients in the series were recorded as being allergic to aspirin. Asthma developed more commonly before polypectomy than after in the ratio of 2.5:1. Around 1 per cent of first polypectomies and 0.5 per cent of all polypectomies were followed by the development of asthma within a few months. The onset of asthma was found to occur most frequently just before or just after the first polypectomy. Those who developed asthma after polypectomy had significantly more polypectomies than both non-asthmatics and those whose asthma preceded their polyps. Though it is possible polypectomy may on rare occasions precipitate asthma, it is felt that it does not cause it.
在一项对445例鼻息肉患者的回顾性研究中，95例（21%）患有哮喘。42例（44%）哮喘患者进行了皮肤试验，其中27例（60%）反应呈阳性。鼻息肉在男性中比女性常见两倍，不过患有鼻息肉的女性患哮喘的可能性是男性的两倍。息肉的平均发病年龄为39岁，哮喘为38岁。不同患者组在息肉或哮喘的发病年龄上未发现显著差异。该系列所有患者中有2%患有鼻息肉、哮喘和对阿司匹林过敏（阿司匹林三联征）。息肉和哮喘患者中有10%对阿司匹林过敏，因此患有完整的三联征。总体而言，该系列所有患者中有6%被记录为对阿司匹林过敏。哮喘在息肉切除术前比术后更常见，比例为2.5:1。大约1%的首次息肉切除术和0.5%的所有息肉切除术后在几个月内出现哮喘。发现哮喘最常在首次息肉切除术之前或之后立即发作。息肉切除术后发生哮喘的患者比非哮喘患者以及哮喘先于息肉出现的患者进行的息肉切除术明显更多。虽然息肉切除术在极少数情况下可能引发哮喘，但人们认为它不会导致哮喘。
