丘脑至皮层癫痫发作通路的频谱分析。

Spectral analysis of a thalamus-to-cortex seizure pathway.

作者信息

Sherman D L, Tsai Y C, Rossell L A, Mirski M A, Thakor N V

机构信息

Department of Biomedical Engineering, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.

出版信息

IEEE Trans Biomed Eng. 1997 Aug;44(8):657-64. doi: 10.1109/10.605422.

DOI:10.1109/10.605422

PMID:9254979

Abstract

Physiological evidence has shown that the anterior thalamus (AN) and its associated efferents/afferents constitute an important propagation pathway for one animal model of generalized tonic-clonic epileptic seizures. In this study we extend and confirm the support for AN's role by examining neuroelectric signal indicators during seizure episodes. We show that the electroencephalogram (EEG) recorded from AN is highly coherent with the EEG derived from the cortex (CTX). By removing the effects of another thalamic nucleus, posterior thalamus (PT)-unaffiliated with the tract linking AN to cortex-partial coherence analysis leaves the CTX/AN coherence undiminished. The most robust band of strong CTX-AN coherence is centered around the spike-wave pacing frequency of 1-3 Hz. Partial-multiple coherence analysis techniques are used to remove the possible signal contribution from hippocampus in addition to PT. The CTX-AN coherence still remains undiminished in the low-frequency bands. Conclusive evidence from coherence studies and other spectral measures reaffirm the special role of the AN in the propagation of seizure activity from subcortex to cortex.

摘要

生理学证据表明，丘脑前核（AN）及其相关的传出/传入神经构成了全身强直阵挛性癫痫发作的一种动物模型的重要传播途径。在本研究中，我们通过检查癫痫发作期间的神经电信号指标来扩展并确认对AN作用的支持。我们发现，从AN记录的脑电图（EEG）与从皮层（CTX）获得的EEG高度相干。通过去除另一个丘脑核团——后丘脑（PT）（与连接AN和皮层的神经束无关）的影响，部分相干分析表明CTX/AN的相干性并未减弱。最强的CTX-AN相干频段集中在1-3Hz的棘慢波起搏频率附近。除了PT之外，还使用部分多重相干分析技术去除海马体可能的信号贡献。在低频段，CTX-AN的相干性仍然没有减弱。来自相干性研究和其他频谱测量的确凿证据再次证实了AN在癫痫活动从皮层下向皮层传播中的特殊作用。