The behavior of endometrial hyperplasia: a prospective study. Endometrial Hyperplasia Study Group.

作者信息

Terakawa N, Kigawa J, Taketani Y, Yoshikawa H, Yajima A, Noda K, Okada H, Kato J, Yakushiji M, Tanizawa O, Fujimoto S, Nozawa S, Takahashi T, Hasumi K, Furuhashi N, Aono T, Sakamoto A, Furusato M

机构信息

Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan.

出版信息

J Obstet Gynaecol Res. 1997 Jun;23(3):223-30. doi: 10.1111/j.1447-0756.1997.tb00836.x.

OBJECTIVE

To clarify the behavior of endometrial hyperplasia in a prospective study.

METHOD

Fifty-one patients with endometrial hyperplasia were followed up for 6 months. Samples of endometrial tissues were taken by uterine endometrial biopsy every 4 weeks during the first 3 months and at the end of follow-up.

RESULTS

In 69% (35/51) of the patients histological picture of the endometrium became normal during the observation period. The lesions persisted in 17% (6/35) of the patients with simple hyperplasia, in 25% (1/4) of those with complex hyperplasia, in 14% (1/7) of those with simple atypical hyperplasia, and in 80% (4/5) of the patients with complex atypical hyperplasia. In the remaining 3 patients with simple hyperplasia, the lesions progressed to complex atypical hyperplasia by the end of follow-up, after showing a normal endometrium.

CONCLUSION

Most cases of endometrial hyperplasia, except for complex atypical hyperplasia, disappeared spontaneously within a short period of time.