Yamada H, Kishida T, Negishi H, Sagawa T, Yamaguchi M, Sato C, Nakamura I, Sato H, Sakai K, Yamaguchi T, Fujimoto S
Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Sapporo, Japan.
J Obstet Gynaecol Res. 1997 Jun;23(3):307-11. doi: 10.1111/j.1447-0756.1997.tb00850.x.
We developed an improved AFP kit for detecting AFP in leaked amniotic fluid. We studied the relationship between the results of the improved AFP kit and those of the intra-amniotic PSP dye-injection test (PSP test), and compared the results of two tests with the prognosis for subsequent pregnancy outcome, in order to know the diagnostic value of the two tests for preterm PROM, especially in equivocal cases.
We compared the results of the AFP kit test with those of the PSP test in 8 equivocal cases of preterm PROM (18th to 34th weeks of gestation).
The results of the AFP kit test coincided with those of the PSP test in all 8 equivocal cases of preterm PROM. The 4 cases that tested positive resulted in preterm deliveries; and the other 4 cases that tested negative resulted in full-term deliveries.
The use of the AFP kit test is useful in assessing the prognosis for subsequent pregnancy in equivocal cases of preterm PROM. The rapid and accurate AFP kit test for diagnosing preterm PROM can be substituted for the PSP test in bedside and outpatient-clinic assessments.
我们研发了一种改良的甲胎蛋白（AFP）检测试剂盒，用于检测羊水渗漏中的AFP。我们研究了改良AFP试剂盒检测结果与羊膜腔内酚红染料注射试验（PSP试验）结果之间的关系，并将两项试验结果与后续妊娠结局的预后进行比较，以了解这两项试验对早产胎膜早破（preterm PROM）的诊断价值，尤其是在疑似病例中。
我们比较了8例早产胎膜早破疑似病例（妊娠第18至34周）的AFP试剂盒检测结果与PSP试验结果。
在所有8例早产胎膜早破疑似病例中，AFP试剂盒检测结果与PSP试验结果一致。检测呈阳性的4例导致早产；检测呈阴性的其他4例则足月分娩。
AFP试剂盒检测在评估早产胎膜早破疑似病例的后续妊娠预后方面很有用。用于诊断早产胎膜早破的快速准确的AFP试剂盒检测可在床边和门诊评估中替代PSP试验。
