磷酸肌醇3激酶：信号转导分子的保守家族。
Phosphoinositide 3-kinases: a conserved family of signal transducers.
作者信息
Vanhaesebroeck B, Leevers S J, Panayotou G, Waterfield M D
机构信息
Ludwig Institute for Cancer Research, London, UK.
出版信息
Trends Biochem Sci. 1997 Jul;22(7):267-72. doi: 10.1016/s0968-0004(97)01061-x.
PMID:9255069
Abstract
Phosphoinositide 3-kinases (PI3Ks) generate lipids that are implicated in receptor-stimulated signalling and in the regulation of membrane traffic. Several distinct classes of PI3Ks have now been identified that have been conserved throughout eukaryotic evolution. Potential signalling pathways downstream of PI3Ks have been elucidated and PI3K function is now being characterised in several model organisms.
摘要
磷酸肌醇3激酶（PI3Ks）产生的脂质参与受体刺激信号传导和膜运输调控。现已鉴定出几类不同的PI3Ks，它们在整个真核生物进化过程中都保守存在。PI3Ks下游的潜在信号通路已得到阐明，目前正在几种模式生物中对PI3K功能进行表征。
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