Matsuura N, Narita T, Mitsuoka C, Kimura N, Kannagi R, Imai T, Funahashi H, Takagi H
Department of Surgery II, Nagoya University School of Medicine, Japan.
Jpn J Clin Oncol. 1997 Jun;27(3):135-9. doi: 10.1093/jjco/27.3.135.
The adhesion of circulating cancer cells to the vascular endothelium is an important at step in the hematogenous metastasis of cancer. E-selectin expressed on endothelial cells and carbohydrate ligands expressed on cancer cells mediate this adhesion. We investigated the clinical significance of such cell adhesion molecules in breast cancer. The cytosol concentration of sialyl Lewis(x) was found more elevated in cancerous tissue than that in adjacent non-cancerous tissue. In the serum, sialyl Lewis(x) and soluble E-selectin were seen elevated in patients with advanced and recurrent breast cancer, especially in those with distant metastases. From the above, we have concluded that sialyl Lewis(x) and soluble E-selectin could be used as tumor markers with a close relationship to the metastasis of breast cancer.
循环癌细胞与血管内皮的黏附是癌症血行转移过程中的重要步骤。内皮细胞上表达的E-选择素和癌细胞上表达的碳水化合物配体介导了这种黏附。我们研究了此类细胞黏附分子在乳腺癌中的临床意义。结果发现，癌组织中唾液酸路易斯（x）的胞浆浓度高于相邻的非癌组织。在血清中，晚期和复发性乳腺癌患者，尤其是有远处转移的患者，唾液酸路易斯（x）和可溶性E-选择素水平升高。综上所述，我们得出结论，唾液酸路易斯（x）和可溶性E-选择素可作为与乳腺癌转移密切相关的肿瘤标志物。
