Ye C, Kiriyama K, Mistuoka C, Kannagi R, Ito K, Watanabe T, Kondo K, Akiyama S, Takagi H
Department of Surgery II, School of Medicine, Nagoya University, Japan.
Int J Cancer. 1995 May 16;61(4):455-60. doi: 10.1002/ijc.2910610404.
E-selectin is an adhesion molecule of endothelial cells that binds to cancer cells mediated by sialyl Lewis A (sLea) or sialyl Lewis X (sLe(x)). It is suspected to be involved in hematogenous metastasis of tumors. Therefore, it is worth examining E-selectin expression in human colorectal cancer and its hepatic metastasis. In the present study, E-selectin was clearly revealed on the endothelial cells of small vessels adjacent to cancer nests both in primary and in metastatic nests in immunohistochemistry. In these tissues, E-selectin was observed on the endothelial cells lining the lumen of small vessels. Its expression adjacent to cancer nests appears to be induced through some stimuli by cancer cells, since its degree of expression is inversely correlated to the distance of the blood vessels from the cancer nests (p < 0.001). Endothelial cells adjacent to the metastatic lesion expressed E-selectin more extensively than those adjacent to the primary foci. This is also in line with the finding on serum E-selectin levels which were significantly elevated in the metastatic group as compared with the non-metastatic group. The serum E-selectin level may provide useful information in the diagnosis for hepatic metastasis of colorectal cancer, although the results are still tentative.
E选择素是内皮细胞的一种黏附分子，它通过唾液酸化路易斯A（sLea）或唾液酸化路易斯X（sLe(x)）介导与癌细胞结合。人们怀疑它参与肿瘤的血行转移。因此，研究人结直肠癌及其肝转移灶中E选择素的表达情况很有必要。在本研究中，免疫组化显示在原发性癌巢和转移癌巢中，紧邻癌巢的小血管内皮细胞上均清晰可见E选择素。在这些组织中，在小血管腔内衬的内皮细胞上观察到了E选择素。其在癌巢附近的表达似乎是由癌细胞的某些刺激诱导产生的，因为其表达程度与血管距癌巢的距离呈负相关（p < 0.001）。转移灶附近的内皮细胞比原发灶附近的内皮细胞更广泛地表达E选择素。这也与血清E选择素水平的研究结果相符，即转移组血清E选择素水平明显高于非转移组。血清E选择素水平可能为结直肠癌肝转移的诊断提供有用信息，尽管结果仍具有初步性。
