Nakayama H, Hirol M, Kiyoku H, Naruse K, Enzan H
First Department of Pathology, Kochi Medical School, Japan.
Jpn J Clin Oncol. 1997 Jun;27(3):200-3. doi: 10.1093/jjco/27.3.200.
We report one rare case of superficial angiomyxoma of the right inguinal region, in a 67-year-old man. The tumor, measuring 4.5 x 4.0 x 3.0 cm, had a finger-like shape, was composed of a well circumscribed conglomerate of multiple myxomatous nodules and was located partially in the dermis and partially in the subcutaneous tissue. Microscopically, in contrast to previously reported cases, the tumor was composed mainly of oval plump stromal cells with an amphophilic cytoplasm. Spindle-shaped stromal cells were scattered throughout the tumor. The tumor border was not infiltrative and was well defined by thick hyalized collagen bundles. Neither hyperchromasia nor pleomorphism was apparent. No mitotic figures were detected in the specimens prepared. Small to medium-sized blood vessels showed a scattered distribution, but large vessels, seen frequently in aggressive angiomyxoma, were absent. Moreover, no plexiform capillary pattern was evident. These findings were diagnostic of superficial angiomyxoma. Although this disease entity is considered as including cutaneous focal mucinosis, follicular fibroma, trichofolliculoma and trichogenic adnexal tumor, we propose that these tumors should be excluded.
我们报告一例罕见的右腹股沟区浅表血管黏液瘤病例，患者为一名67岁男性。肿瘤大小为4.5×4.0×3.0厘米，呈指状，由多个黏液瘤性结节组成的边界清楚的团块构成，部分位于真皮，部分位于皮下组织。显微镜下，与先前报道的病例不同，肿瘤主要由具有嗜双色性细胞质的椭圆形丰满间质细胞组成。梭形间质细胞散在于整个肿瘤中。肿瘤边界无浸润，由增厚的玻璃样变胶原束清晰界定。未见核深染及异形性。在制备的标本中未检测到有丝分裂象。中小血管呈散在分布，但未见侵袭性血管黏液瘤中常见的大血管。此外，未见丛状毛细血管模式。这些表现可诊断为浅表血管黏液瘤。尽管该疾病实体被认为包括皮肤局灶性黏液病、毛囊纤维瘤、毛发滤泡瘤和毛发发生附属器肿瘤，但我们建议应排除这些肿瘤。
