Jehl-Pietri C, Monteil R, Madinier I, Raybaud-Diogène H, Bracco M
Laboratoire de Pathobiologie Orale, Université de Nice Sophia-Antipolis.
Ann Med Interne (Paris). 1997;148(3):209-16.
Xerostomia is a marked reduction in saliva production and may occur as an early symptom of various systemic diseases. It is also secondary to the administration of numerous drugs. Severity of salivary gland dysfunction cannot be predicted from subjective reports of oral dryness by patient, and accurate assessments of salivary gland function should be managed. Several procedures for saliva samplings and secretory activity measurements have been reported. In normal individuals, the mean values of unstimulated whole saliva was slightly higher in males (0.42 ml/min) than in females (0.37 ml/min). Corresponding mean values for stimulated whole saliva are 1.77 ml/min and 1.38 ml/min. Unstimulated whole saliva collection during 15 min is recommended as the most reliable test for clinical diagnosis. It is found that an unstimulated salivary flow of 0.1 ml/min represents the cut-off limit for the diagnosis of xerostomia.
口干症是指唾液分泌显著减少,可能是多种全身性疾病的早期症状。它也继发于多种药物的使用。患者关于口腔干燥的主观报告无法预测唾液腺功能障碍的严重程度,因此应进行唾液腺功能的准确评估。已经报道了几种唾液采样和分泌活性测量的方法。在正常个体中,男性未刺激全唾液的平均值(0.42毫升/分钟)略高于女性(0.37毫升/分钟)。刺激全唾液的相应平均值分别为1.77毫升/分钟和1.38毫升/分钟。建议在15分钟内收集未刺激全唾液作为临床诊断最可靠的测试。发现未刺激唾液流速为0.1毫升/分钟是诊断口干症的临界值。